Tuesday, May 15, 2012

Vitamin B12 and infant brain development

In a new study in the European Journal of Paediatric Neurology, cranial MRI images were taken of 15 infants with vitamin B12 deficiency.
In our study, thinning of the corpus callosum was detected in 6 (40%), cortical atrophy in 5 (33.3%), ventricular dilatation in 3 (20%), large sylvian fissures in 5 (33.3%), hydrocephalus in 3 (20%), asymetric large lateral ventricule in 2 (13.3%) and retardation in myelination in 2 (13.3%) patients and 4 infants had normal MRI findings, respectively.
In conclusion, vitamin B12 is important for development of brain. Severe and various neurological and neuroradiological findings may be seen in infants due to vitamin B12 deficiency. Vitamin B12 deficiency should be considered in infants with hypotonia or neurodevelopmental retardation and with neuroradiological findings such as thinning of the corpus callosum, cortical atrophy and retardation in myelination. The early diagnosis and treatment of vitamin B12 deficiency is crucial for significant neurological impairment and long-term prognosis. Vitamin B12 supplementation of pregnant women may prevent neurological and neuroradiological findings of the infants.
It is infants breastfed by vegetarian mothers who are most at risk of vitamin B12 deficiency. This is true in both undeveloped and developed countries.


  1. HBDers say that aid to Africa should be cut because Africans are not born smart enough to build functional societies and the money just gets wasted. Isn't evidence of all the non-genetic but biological things like this that affect brain development a case for more aid? At least in health care.

  2. I think we should supply enough vitamin b12 supplements on areas that need the support that we can for preventing the wide spread deficient victims.

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