Friday, May 08, 2020

New study: More African ancestry predicts reduced lung function in Puerto Ricans


















Abstract

Introduction: In the U.S., asthma disproportionately affects urban minority populations, with Puerto Ricans showing the highest asthma prevalence 16.1%. However, what causes high asthma
prevalence among the Puerto Ricans is not very well understood. The varying proportions of African, European, and Native American genetic ancestry in Puerto Ricans can be leveraged to identify genetic determinants of clinically significant measures and outcomes such as lung function and asthma severity. We have previously demonstrated that genetic ancestry is associated with lung function.

Methods: In this current study, we sought to discover potential causal genes that may be associated with lung function in Puerto Rican islanders by applying admixture and fine mapping methods. A genome-wide admixture mapping study of lung function was conducted in 841 Puerto Rican children with and without asthma, who were recruited from Puerto Rico. After mapping admixture segments, we fine-mapped the genomic region using whole genome sequencing data. RNA-seq and eQTL mapping were used to elucidate underlying biologic links between genetic variants and lung function.

Results: The association test between local genetic ancestry and forced expiratory volume in 1 second (FEV1) identified a strong admixture mapping peak on chromosome 1q32, indicating that each African ancestry allele was associated with a 0.13 liter decrease in the volume of exhaled air [95%CI: -0.08 to -0.18, p-value=4.90×10-8]. Three variants identified from the fine-mapping analysis were eQTL of TMEM9 gene in nasal epithelial cell. The minor allele of the variant associated with TMEM9 gene (rs10920079) tracked with African ancestry and was associated with significantly decreased lung function and TMEM9 gene expression. TMEM9 was inversely correlated with proinflammatory cytokine IL-6 and IL-1β gene expressions.

Conclusion: The results from admixture mapping discovered variants that were associated with decreased lung function. Functional annotation and validation with RNA-seq and eQTL mapping indicate that these SNPs may be involved with regulating cytokine production, which may influence the lung function of Puerto Ricans.

4 comments:

  1. This comment has been removed by a blog administrator.

    ReplyDelete
    Replies
    1. I thought the physicians said there is no pills or another way for PENIS ENLARGEMENT !!! I am telling you today that Dr Aziba has the product for PENIS ENLARGEMENT and it worked perfectly for me from 3:0 to 8:95 and still counting. Contact Dr Aziba for help to Enlarge your penis via Email him via: (Priestazibasolutioncenter@gmail.com) and WhatsApp Him on +2348100368288 website https://naturalherbsmedicine.webs.com/
      FACEBOOK PAGE: ( @DOCTOR AZIBA) and please lets keep sharing this solution to other fellow men around the Global with living with such mess.

      Delete
  2. I'm 57 years old and female. I was diagnosed a couple of years ago with COPD and I was beyond scared! My lung function test indicated 49% capacity. After having had flu a year ago, the shortness of breath, coughing and chest pains continued even after being treated with antibiotics. I've been smoking two packs a day for 36 years. Being born without a sternum caused my ribs to be curled in just one inch away from my spine, resulting to underdeveloped lungs. At age 34 I had surgery and it was fixed. Unfortunately my smoking just caused more damage to my already under developed lungs. The problem was having is that I enjoy smoking and don't want to give up! Have tried twice before and nearly went crazy and don't want to go through that again. I saw the fear in my husband and children's eyes when I told them about my condition then they start to find solution on their own to help my condition.I am an 57 now who was diagnose COPD emphysema which I know was from my years of smoking. I started smoking in school when smoking was socially acceptable. I remember when smoking was permitted in hospitals. It was not known then how dangerous cigarettes were for us, and it seemed everybody smoked but i was able to get rid of my COPD lung condition through the help of  Dr Akhigbe   total cure herbal medicine. my husband saw his testimony on the internet he used his powerful medicine to cured different diseases. we contacted his email   [drrealakhigbe@gmail.com}   He has the right herbal formula to help you get rid and repair any lung conditions and others diseases, will cure you totally and permanently with his natural organic herbs,We received the medicine through courier delivery service. I wish anybody who starts smoking at a young age would realize what will eventually happen to their bodies if they continue that vile habit throughout their life.
    Dr Akhighe also cured diseases like, HERPES, DIABETES, HIV/AIDS, COPD, CANCER,ASTHMA,STROKE,LUPUS,JOINT PAIN,CHRONIC DISEASES,PARKINSON DISEASES,TUBERCULOSIS,HIGH BLOOD PRESSURE,BREAST INFECTION,WOMEN SEXUAL PROBLEM, GINGIVITIS, ERYSIPELAS,STAPHYLOCOCCUS,HEPATITIS A/B, QUICK EJACULATION, IMMUNOTHERAPY, GONORRHEA,SYPHILIS,WAST/BACK PAIN,PELVIC INFLAMMATORY, DICK ENLARGEMENT,HEART DISEASES,TERMINAL ILLNESS,SHIFT IN FOCUS,ATAXIA,COMMON COLD,CROHN'S DISEASES,ALCOHOL SPECTRUM DISORDER,GRAVES DISEASE,HEARING LOSS, INTERSTITIA CYSTITIS,LEUKEMIA,MULTIPLE SCLEROSIS,OBESITY,RABIES,SCOLIOSIS,INFLUENZA, POLIO,JACOB,ETC. If you are out there looking for your cure please  contact  dr Akhigbe  by his email    drrealakhigbe@gmail.com     or contact his whatsapp number   +2349010754824
    God bless you Dr Akhigbe for your good hand work on my life.

    ReplyDelete
  3. I thought the physicians said there is no pills or another way for PENIS ENLARGEMENT !!! I am telling you today that Dr Aziba has the product for PENIS ENLARGEMENT and it worked perfectly for me from 3:0 to 8:95 and still counting. Contact Dr Aziba for help to Enlarge your penis via Email him via: (Priestazibasolutioncenter@gmail.com) and WhatsApp Him on +2348100368288 website https://naturalherbsmedicine.webs.com/
    FACEBOOK PAGE: ( @DOCTOR AZIBA) and please lets keep sharing this solution to other fellow men around the Global with living with such mess.

    ReplyDelete

GSS data: Trump-voting women are happier and here's why

Feminism is a form of liberation that should make you happy, right? Wrong. Here is the relationship among white women between being happy an...